Back to Search
Start Over
Sex difference of mortality by age and body mass index in gastric cancer.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2021 Sep; Vol. 53 (9), pp. 1185-1191. Date of Electronic Publication: 2021 Jun 08. - Publication Year :
- 2021
-
Abstract
- Mortality difference by age, sex, body mass index (BMI) in gastric cancer (GC) has been controversial. We evaluated sex-specific mortality by age and BMI. A total of 5961 patients diagnosed with GC from 2005 to 2013 in a single tertiary center were included and were followed until December 2017. The plot in goodness-of-fit-test by sex was crossed, so we performed sex-specific analysis. Overall mortality was lower in women than in men (adjusted hazard ratio [aHR], 0.72). Favor outcomes in women compared to men were observed among patients older than 60 yr (aHR, 0.64; 95% CI, 0.56-0.74), a BMI less than 25 kg/m <superscript>2</superscript> (aHR, 0.69; 95% CI, 0.61-0.79), and stage I (aHR, 0.46; 95% CI, 0.38-0.56). In sex-specific analysis, mortality increased in age older than 60 yr in men, whereas it increased in both extreme ages (<40 yr and ≥ 70 yr) in women. Mortality by BMI was lowest at BMI of 25-29.9 kg/m <superscript>2</superscript> and gradually increased according to decrease of BMI in men; aHR, 1.24 (23-24.9 kg/m <superscript>2</superscript> ), 1.44 (18.5-22.9 kg/m <superscript>2</superscript> ), and 2.54 (BMI<18.5 kg/m <superscript>2</superscript> ). However, mortality decreased in patients with BMI ≥ 30 kg/m <superscript>2</superscript> (aHR, 0.46) in women. The sex discrepancies in GC mortality by age and BMI suggest the need for sex-specific approaches to prognostic prediction.<br />Competing Interests: Declaration of Competing Interest None declared.<br /> (Copyright © 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 53
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 34112614
- Full Text :
- https://doi.org/10.1016/j.dld.2021.05.006