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TMSB10, a potential prognosis prediction biomarker, promotes the invasion and angiogenesis of gastric cancer.
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2021 Nov; Vol. 36 (11), pp. 3102-3112. Date of Electronic Publication: 2021 Aug 26. - Publication Year :
- 2021
-
Abstract
- Background and Aim: The thymosin beta 10 (TMSB10) was originally identified from the thymus, which plays a key role in the development of many cancers. However, the underlying molecular mechanisms of TMSB10 involved in GC have not been understood.<br />Methods: We sought to determine the expression of TMSB10 in human GC tissues and illustrate whether it is correlated with the clinical pathologic characteristics and prognosis in GC patients. Its roles and potential mechanisms in regulating tumor growth, invasion, and angiogenesis were evaluated by TMSB10 knockdown/overexpression of GC cells in vitro and ex vivo.<br />Results: Marked overexpression of TMSB10 protein expression was observed in GC cells and tissues, which was associated with the advanced tumor stage and lymph nodes (LN) metastasis of GC patients. Furthermore, prognostic analysis showed that GC patients with high TMSB10 expression had a remarkably shorter survival and acted as an important factor for predicting poor overall survival in GC patients. Moreover, TMSB10 overexpression promoted, while TMSB10 knockdown the proliferation, EMT process, and angiogenesis of GC cells.<br />Conclusion: The study highlights that TMSB10 may hold promise as potential prognosis prediction biomarker for the diagnosis of GC and a potential therapeutic target, which will facilitate the development of a novel therapeutic strategy against GC.<br /> (© 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Biomarkers, Tumor biosynthesis
Biomarkers, Tumor genetics
Cell Line, Tumor
Cell Movement
Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Lymphatic Metastasis
Neoplasm Invasiveness
Neovascularization, Pathologic
Prognosis
Stomach Neoplasms genetics
Stomach Neoplasms metabolism
Stomach Neoplasms pathology
Thymosin biosynthesis
Thymosin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1746
- Volume :
- 36
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 34114679
- Full Text :
- https://doi.org/10.1111/jgh.15576