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Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2021 Jun 12; Vol. 32 (6), pp. 67. Date of Electronic Publication: 2021 Jun 12. - Publication Year :
- 2021
-
Abstract
- The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Infective Agents
Antioxidants chemistry
Bandages
Benzothiazoles chemistry
Biphenyl Compounds chemistry
Cell Line
Cell Survival
Cross-Linking Reagents chemistry
Drug Liberation
Escherichia coli metabolism
Gels
Humans
Hydrogen Bonding
Keratinocytes metabolism
Microscopy, Electron, Scanning
NF-kappa B metabolism
Picrates chemistry
Spectroscopy, Fourier Transform Infrared
Stress, Mechanical
Sulfonic Acids chemistry
Temperature
Cellulose chemistry
Chitosan chemistry
Keratinocytes drug effects
Polyphenols chemistry
Tannins chemistry
Wound Healing
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34117926
- Full Text :
- https://doi.org/10.1007/s10856-021-06536-4