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Body mass index and survival of patients with lymphoma.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2021 Nov; Vol. 62 (11), pp. 2671-2678. Date of Electronic Publication: 2021 Jun 14. - Publication Year :
- 2021
-
Abstract
- The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p =.004) and for those with a ≥ 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p =.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.
- Subjects :
- Body Mass Index
Cohort Studies
Humans
Prospective Studies
Leukemia, Lymphocytic, Chronic, B-Cell diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell epidemiology
Lymphoma, Follicular diagnosis
Lymphoma, Follicular epidemiology
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 62
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 34121594
- Full Text :
- https://doi.org/10.1080/10428194.2021.1929956