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ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis.
- Source :
-
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2021 Sep; Vol. 35, pp. 102395. Date of Electronic Publication: 2021 Jun 11. - Publication Year :
- 2021
-
Abstract
- 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment modality for premalignant and malignant skin lesions. It has the advantage of better tolerance and providing better cosmetic outcomes than conventional treatment methods. Herein, we report a patient who suffered from multiple cutaneous squamous cell carcinoma (cSCC) in situ and actinic keratosis (AK) scattered in the body's sun-exposed areas, which had led him to undergo multiple surgical resections since the age of 16. Next-generation sequencing-based on a targeted gene capture panel revealed compound heterozygous mutations c.G559A and c.G1389A in the TMC8 gene. Combined with the typical clinical manifestations and mutation analysis, the patient was diagnosed with Epidermodysplasia verruciformis (EV). Due to the multiple AK and cSCC in situ lesions, ALA-PDT was applied. After 8 courses of ALA-PDT all lesions were successfully cleared without causing any scarring. Therefore, the use of ALA-PDT treatment may constitute a very promising and effective therapeutic modality for multiple cSCC in situ and AK secondary to EV.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Aminolevulinic Acid therapeutic use
Humans
Male
Membrane Proteins
Photosensitizing Agents therapeutic use
Treatment Outcome
Carcinoma, Squamous Cell drug therapy
Epidermodysplasia Verruciformis drug therapy
Keratosis, Actinic drug therapy
Photochemotherapy methods
Skin Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1597
- Volume :
- 35
- Database :
- MEDLINE
- Journal :
- Photodiagnosis and photodynamic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 34126243
- Full Text :
- https://doi.org/10.1016/j.pdpdt.2021.102395