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GLIS1, a potential candidate gene affect fat deposition in sheep tail.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2021 May; Vol. 48 (5), pp. 4925-4931. Date of Electronic Publication: 2021 Jun 16. - Publication Year :
- 2021
-
Abstract
- Fat deposition in sheep tails is as a result of a complicated mechanism. Mongolian sheep (MG) and Small Tail Han sheep (STH) are two fat-tailed Chinese indigenous sheep breeds while DairyMeade and East Friesian (DS) are two thin-tailed dairy sheep breeds recently introduced to China. In this study, population genomics analysis was applied to identify candidate genes associated with sheep tails based on an in-depth whole-genome sequencing of MG, STH and DS. The selective signature analysis demonstrated that GLIS1, LOC101117953, PDGFD and T were in the significant divergent regions between DS and STH-MG. A nonsynonymous point mutation (g.27807636G>T) was found within GLIS1 in STH-MG and resulted in a Pro to Thr substitution. As a pro-adipogenic factor, GLIS1 may play critical roles in the mesodermal cell differentiation during fetal development affecting fat deposition in sheep tails. This study gives a new insight into the genetic basis of species-specific traits of sheep tails.
- Subjects :
- Animals
China
Genomics
Metagenomics
Mutation
Platelet-Derived Growth Factor genetics
Platelet-Derived Growth Factor metabolism
Polymorphism, Single Nucleotide
Transcription Factors genetics
Transcription Factors metabolism
Whole Genome Sequencing
Lipid Metabolism genetics
Sheep, Domestic genetics
Sheep, Domestic metabolism
Tail metabolism
Zinc Fingers genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 34132943
- Full Text :
- https://doi.org/10.1007/s11033-021-06468-w