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Longitudinal high-resolution imaging through a flexible intravital imaging window.
- Source :
-
Science advances [Sci Adv] 2021 Jun 16; Vol. 7 (25). Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Intravital microscopy (IVM) is a powerful technique that enables imaging of internal tissues at (sub)cellular resolutions in living animals. Here, we present a silicone-based imaging window consisting of a fully flexible, sutureless design that is ideally suited for long-term, longitudinal IVM of growing tissues and tumors. Crucially, we show that this window, without any customization, is suitable for numerous anatomical locations in mice using a rapid and standardized implantation procedure. This low-cost device represents a substantial technological and performance advance that facilitates intravital imaging in diverse contexts in higher organisms, opening previously unattainable avenues for in vivo imaging of soft and fragile tissues.<br /> (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)
Details
- Language :
- English
- ISSN :
- 2375-2548
- Volume :
- 7
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Science advances
- Publication Type :
- Academic Journal
- Accession number :
- 34134982
- Full Text :
- https://doi.org/10.1126/sciadv.abg7663