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Prognostic value of cardiopulmonary exercise test after heart transplantation.

Authors :: Iglesias D
Masson W
Barbagelata L
Rossi E
Mora M
Cornejo G
Lagoria J
Belziti C
Vulcano N
Marenchino R
Pizarro R
Ventura H
Source :: Clinical transplantation [Clin Transplant] 2021 Aug; Vol. 35 (8), pp. e14387. Date of Electronic Publication: 2021 Jun 28.
Publication Year :: 2021
Abstract: Background: The clinical utility of cardiopulmonary exercise testing (CPET) has not been extensively studied yet in heart transplantation (HTX) patients. Objective: To analyze the predictive value of the CPET on hospitalizations and mortality in HTX recipients. Methods: A retrospective cohort was performed from a secondary database. Patients > 18 years with HTX who underwent a CPET between 3 and 12 months after transplantation were included. Time to the first primary endpoint (HTX-related hospitalization) was analyzed and adjusted using Cox proportional hazards regression model. Results: A total of 122 patients (mean age 50.1 years, 77.0% men) were included. Fifty-seven patients (46.7%) had the primary endpoint. Peak VO <subscript>2</subscript> (HR .95; CI 95% .90-.99, P = .03), oxygen pulse (HR .57; CI 95% .34-.96, P = .03) and predicted VO <subscript>2</subscript> (HR .97; CI 95% .96-.99, P = .002) were associated with the endpoint. We did not find a significant association between the other variables and the outcome. Conclusion: In HTX recipients, peak VO <subscript>2</subscript> , oxygen pulse, and predicted VO <subscript>2</subscript> were independently associated with hospitalizations at follow up. (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)