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Polymer nanoparticles regulate macrophage repolarization for antitumor treatment.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jul 18; Vol. 57 (56), pp. 6919-6922. Date of Electronic Publication: 2021 Jun 22. - Publication Year :
- 2021
-
Abstract
- We demonstrate an intrinsic antitumor effect of polymer nanoparticles (P-NPs), which could re-program tumor-associated macrophages to pro-inflammatory phenotype. The intrinsic effect of P-NPs on macrophage repolarization and its combination with other therapies provide new ideas for drug delivery, macrophage regulation and immunotherapy in cancer treatment.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents toxicity
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Drug Screening Assays, Antitumor
Maleates chemistry
Maleates toxicity
Mice
Nanoparticles toxicity
Polystyrenes chemistry
Polystyrenes toxicity
Polyvinyls chemistry
Polyvinyls toxicity
Antineoplastic Agents pharmacology
Macrophage Activation drug effects
Macrophages drug effects
Maleates pharmacology
Nanoparticles chemistry
Polystyrenes pharmacology
Polyvinyls pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 56
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34155490
- Full Text :
- https://doi.org/10.1039/d1cc02678j