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Spindle Cell Squamous Cell Carcinoma of the Larynx with Malignant Osteoid Differentiation: A Case Report and Review of Literature.
- Source :
-
Annals of clinical and laboratory science [Ann Clin Lab Sci] 2021 May; Vol. 51 (3), pp. 415-421. - Publication Year :
- 2021
-
Abstract
- Spindle cell squamous cell carcinoma of the larynx is a rare, aggressive variant of squamous cell carcinoma. It comprises 0.6-1.5% of all laryngeal cancers. Heterologous mesenchymal differentiation as bone, cartilage, and muscle is uncommon, especially malignant osteoid differentiation, as a handful of cases reported in the literature. We present the case of a 66-year-old male active smoker who presented with dysphonia and acute stridor. On examination, a 2.0 cm pedunculated, broad-base, glottic mass involving the left true vocal cord and ventricle was noted, with extension to the anterior commissure causing a narrowing of the airway. The patient underwent localized left vocal cordectomy. The histopathologic and immunohistochemical findings were consistent with spindle cell carcinoma with malignant osteoid differentiation. The patient is alive, status-post adjuvant five cycles of cisplatin therapy, with no recurrence at 18 months of follow-up. We discuss a literature review of this rare entity with either malignant osteoid or osteocartilaginous differentiation.<br /> (© 2021 by the Association of Clinical Scientists, Inc.)
- Subjects :
- Aged
Bone Neoplasms therapy
Humans
Laryngeal Neoplasms therapy
Male
Osteoma, Osteoid therapy
Squamous Cell Carcinoma of Head and Neck therapy
Bone Neoplasms pathology
Cell Differentiation
Laryngeal Neoplasms pathology
Osteoma, Osteoid pathology
Squamous Cell Carcinoma of Head and Neck pathology
Vocal Cords pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-8080
- Volume :
- 51
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of clinical and laboratory science
- Publication Type :
- Academic Journal
- Accession number :
- 34162573