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Visible-Light-Driven Redox Neutral Direct C-H Amination of Glycine Derivatives and Peptides with N-Acyloxyphthalimides.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Sep 01; Vol. 27 (49), pp. 12540-12544. Date of Electronic Publication: 2021 Jul 12. - Publication Year :
- 2021
-
Abstract
- A room temperature, visible-light-promoted and redox neutral direct C-H amination of glycine and peptides has been firstly accomplished by using N-acyloxyphthalimide or -succinimide as nitrogen-radical precursor. The present strategy provides ways to introduce functionalities such as N-acyloxyphthalimide or -succinimide specifically to terminal glycine segment of peptides. Herein, mild conditions and high functional-group tolerance allow the preparation of non-natural α-amino acids and modification of corresponding peptides in this way.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Amination
Catalysis
Oxidation-Reduction
Glycine
Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 27
- Issue :
- 49
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 34164860
- Full Text :
- https://doi.org/10.1002/chem.202101982