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Centimeter-scale wide-field-of-view laser-scanning photoacoustic microscopy for subcutaneous microvasculature in vivo .
- Source :
-
Biomedical optics express [Biomed Opt Express] 2021 Apr 28; Vol. 12 (5), pp. 2996-3007. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- We developed a simple and compact laser-scanning photoacoustic microscopy (PAM) for imaging large areas of subcutaneous microvasculature in vivo. The reflection-mode PAM not only retains the advantage of high scanning speed for optical scanning, but also offers an imaging field-of-view (FOV) up to 20 × 20 mm <superscript>2</superscript> , which is the largest FOV available in laser-scanning models so far. The lateral resolution of the PAM system was measured to be 17.5 µm. Image experiments on subcutaneous microvasculature in in vivo mouse ears and abdomen demonstrate the system's potential for fast and high-resolution imaging for injuries and diseases of large tissues and organs.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)
Details
- Language :
- English
- ISSN :
- 2156-7085
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomedical optics express
- Publication Type :
- Academic Journal
- Accession number :
- 34168911
- Full Text :
- https://doi.org/10.1364/BOE.426366