On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.

Authors :: Houck DR
Ondeyka J
Zink DL
Inamine E
Goetz MA
Hensens OD
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 1988 Jul; Vol. 41 (7), pp. 882-91.
Publication Year :: 1988
Abstract: Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that asperlicin is biosynthesized from tryptophan, anthranilate and leucine. The resting cell system was used also to prepare 25 asperlicin analogs via directed biosynthesis in presence of analogs of tryptophan and leucine.

Subjects :: Amino Acids metabolism
Fermentation
Aspergillus metabolism
Benzodiazepinones biosynthesis
Cholecystokinin antagonists & inhibitors

Full Text Access

Tools