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Fully implantable and bioresorbable cardiac pacemakers without leads or batteries.
- Source :
-
Nature biotechnology [Nat Biotechnol] 2021 Oct; Vol. 39 (10), pp. 1228-1238. Date of Electronic Publication: 2021 Jun 28. - Publication Year :
- 2021
-
Abstract
- Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.<br /> (© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Details
- Language :
- English
- ISSN :
- 1546-1696
- Volume :
- 39
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 34183859
- Full Text :
- https://doi.org/10.1038/s41587-021-00948-x