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Framing Effects on Decision-Making for Diagnostic Genetic Testing: Results from a Randomized Trial.
- Source :
-
Genes [Genes (Basel)] 2021 Jun 20; Vol. 12 (6). Date of Electronic Publication: 2021 Jun 20. - Publication Year :
- 2021
-
Abstract
- Genetic testing is increasingly part of routine clinical care. However, testing decisions may be characterized by regret as findings also implicate blood relatives. It is not known if genetic testing decisions are affected by the way information is presented (i.e., framing effects). We employed a randomized factorial design to examine framing effects on hypothetical genetic testing scenarios (common, life-threatening disease and rare, life-altering disease). Participants ( n = 1012) received one of six decision frames: choice, default ( n = 2; opt-in, opt-out), or enhanced choice ( n = 3, based on the Theory of Planned Behavior). We compared testing decision, satisfaction, regret, and decision cognitions across decision frames and between scenarios. Participants randomized to 'choice' were least likely to opt for genetic testing compared with default and enhanced choice frames (78% vs. 83-91%, p < 0.05). Neither satisfaction nor regret differed across frames. Perceived autonomy (behavioral control) predicted satisfaction (B = 0.085, p < 0.001) while lack of control predicted regret (B = 0.346, p < 0.001). Opting for genetic testing did not differ between disease scenarios ( p = 0.23). Results suggest framing can nudge individuals towards opting for genetic testing. These findings have important implications for individual self-determination in the genomic era. Similarities between scenarios with disparate disease trajectories point to possible modular approaches for web-based decisional support.
- Subjects :
- Adult
Female
Hereditary Breast and Ovarian Cancer Syndrome diagnosis
Hereditary Breast and Ovarian Cancer Syndrome psychology
Humans
Hypogonadism diagnosis
Hypogonadism psychology
Male
Middle Aged
Patient Education as Topic
Choice Behavior
Genetic Counseling psychology
Genetic Testing
Hereditary Breast and Ovarian Cancer Syndrome genetics
Hypogonadism genetics
Patient Preference
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4425
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Genes
- Publication Type :
- Academic Journal
- Accession number :
- 34202935
- Full Text :
- https://doi.org/10.3390/genes12060941