Prostate Cancer Predisposition.

Authors :: Bhanji Y
Isaacs WB
Xu J
Cooney KA
Source :: The Urologic clinics of North America [Urol Clin North Am] 2021 Aug; Vol. 48 (3), pp. 283-296. Date of Electronic Publication: 2021 Jun 12.
Publication Year :: 2021
Abstract: The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessment, and how genetic risk factors affect aggressiveness and lethality of PCa.<br />Competing Interests: Disclosure The generous support from the Patrick C Walsh Hereditary Prostate Cancer program is gratefully acknowledged. This study was supported by grants from Department of Defense (W81XWH-16-1-0764, W81XWH-16-1-0765, and W81XWH-16-1-0766).<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)