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[Clinical aspects in the diagnosis and treatment of prostate cancer].
- Source :
-
Der Radiologe [Radiologe] 2021 Sep; Vol. 61 (9), pp. 795-801. Date of Electronic Publication: 2021 Jul 02. - Publication Year :
- 2021
-
Abstract
- Background: Diagnosis and treatment of primary prostate cancer (PCA) have undergone significant changes in the last few years due to modern imaging.<br />Objectives: Established and modern diagnostic and therapeutic modalities for detection and treatment of primary PCA are presented and discussed critically.<br />Materials and Methods: Background knowledge and guideline recommendations on primary PCA are summarized and additional information from relevant publications is given.<br />Results: Modern imaging, in particular multiparametric magnetic resonance imaging (mpMRI), has revolutionized the diagnostic work-up of primary PCA. Due to mpMRI, tumors are detected significantly better in both initial and re-biopsy with a significant reduction of overdiagnosis of clinically insignificant PCA. Therapeutic approaches such as active surveillance, radical prostatectomy and focal therapies are increasingly being planned and carried out relying on MR-imaging information concerning tumor extent and tumor aggressiveness. In addition, prostate-specific membrane antigen-positron emission tomography/computed tomography (PSMA-PET/CT) has shown superiority in assessing patients with suspected biochemical recurrence and in primary staging of PCA compared to conventional imaging in terms of detection of metastases.<br />Conclusions: Modern imaging, especially mpMRI and PSMA-PET/CT, has added substantial benefits in modern diagnosis and treatment of primary PCA. Moreover, multiparametric ultrasound is also a promising addition to the radiological armamentarium in the management of primary PCA.<br /> (© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Details
- Language :
- German
- ISSN :
- 1432-2102
- Volume :
- 61
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Der Radiologe
- Publication Type :
- Academic Journal
- Accession number :
- 34213623
- Full Text :
- https://doi.org/10.1007/s00117-021-00869-5