Back to Search
Start Over
The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Jun 18; Vol. 12, pp. 668528. Date of Electronic Publication: 2021 Jun 18 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- The microenvironments formed by cortical (c) and medullary (m) thymic epithelial cells (TECs) play a non-redundant role in the generation of functionally diverse and self-tolerant T cells. The role of TECs during the first weeks of the murine postnatal life is particularly challenging due to the significant augment in T cell production. Here, we critically review recent studies centered on the timely coordination between the expansion and maturation of TECs during this period and their specialized role in T cell development and selection. We further discuss how aging impacts on the pool of TEC progenitors and maintenance of functionally thymic epithelial microenvironments, and the implications of these chances in the capacity of the thymus to sustain regular thymopoiesis throughout life.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Pinheiro and Alves.)
- Subjects :
- Age Factors
Animals
Cellular Microenvironment
Epithelial Cells immunology
Humans
Self Tolerance
Stem Cells immunology
T-Lymphocytes immunology
Thymocytes immunology
Thymus Gland immunology
Cell Differentiation
Cell Proliferation
Epithelial Cells physiology
Stem Cells physiology
Thymus Gland physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34220815
- Full Text :
- https://doi.org/10.3389/fimmu.2021.668528