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Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats.
- Source :
-
BioMed research international [Biomed Res Int] 2021 Jun 15; Vol. 2021, pp. 3565360. Date of Electronic Publication: 2021 Jun 15 (Print Publication: 2021). - Publication Year :
- 2021
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Abstract
- Melatonin (ML) is a potent antioxidant that reduces oxidative stress. This study was designed to examine the protective effect of melatonin on potassium dichromate- (PDC-) induced male reproductive toxicity. Forty rats were divided into five groups: the control group, rats administered PDC orally (10 mg/kg body weight) for eight weeks, rats administered ML intraperitoneally at doses of either 2.5 or 5 mg/kg followed by the administration of PDC, and rats administered 5 mg/kg ML only. The treatment of rats with PDC led to a decrease in the levels of plasma sex hormones, glutathione, superoxide dismutase, catalase, carnitine, sperm count, and motility. Testicular malondialdehyde levels, nitric oxide concentrations, and abnormalities increased significantly in the PDC group. Melatonin administration to the PDC-treated rats reduced the increase of malondialdehyde and restored the activity of antioxidant enzymes (superoxide dismutase and catalase), glutathione, and sex hormone levels. Moreover, ML attenuated PDC-induced increase in levels of tumor necrosis factor-alpha or interleukin-6. ML alleviated histopathological changes and an increase of p53-positive immune reaction due to PDC. Furthermore, ML inhibited PDC-induced decrease in the DNA content of spermatogenic cells. This study proposed that melatonin may be useful in mitigating oxidative stress-induced testicular damage due to potassium dichromate toxicity.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2021 Samir A. E. Bashandy et al.)
- Subjects :
- Animals
Antioxidants metabolism
Body Weight
Catalase metabolism
Chromatography, High Pressure Liquid
Glutathione metabolism
Gonadal Steroid Hormones blood
Inflammation
Lipid Peroxidation
Male
Organ Size
Rats
Rats, Wistar
Sperm Count
Sperm Motility drug effects
Spermatozoa
Superoxide Dismutase metabolism
Melatonin pharmacology
Oxidative Stress
Potassium Dichromate
Testis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2021
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 34222468
- Full Text :
- https://doi.org/10.1155/2021/3565360