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Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jul 28; Vol. 57 (59), pp. 7296-7299. Date of Electronic Publication: 2021 Jul 05. - Publication Year :
- 2021
-
Abstract
- A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.
- Subjects :
- Animals
Cell Line
Cell Survival drug effects
Chlorophyllides
Curcumin chemistry
Curcumin metabolism
Curcumin pharmacology
Humans
Mice
Microscopy, Confocal
Neoplasms drug therapy
Neoplasms pathology
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Photosensitizing Agents therapeutic use
Porphyrins chemistry
Porphyrins metabolism
Porphyrins pharmacology
Reactive Oxygen Species metabolism
Thioredoxin-Disulfide Reductase antagonists & inhibitors
Thioredoxin-Disulfide Reductase metabolism
Transplantation, Heterologous
Tumor Microenvironment
Nanomedicine
Photochemotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 59
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34223569
- Full Text :
- https://doi.org/10.1039/d1cc02318g