Back to Search
Start Over
Novel MLL/KMT2A-MON2 fusion in a child with therapy-related acute myeloid leukemia after treatment for acute promyelocytic leukemia.
- Source :
-
Molecular carcinogenesis [Mol Carcinog] 2021 Nov; Vol. 60 (11), pp. 721-725. Date of Electronic Publication: 2021 Jul 08. - Publication Year :
- 2021
-
Abstract
- Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), which is characterized by the reciprocal t (15;17) (q24; q21) translocation, resulting in PML-RARA gene fusion. Therapy-related AML (t-AML) is a serious complication after cytotoxic and/or radiation therapy in many malignant diseases. In this report, MLL/KMT2A-MON2, with balanced chromosomal translocation t (11;12) (q23; q14), was identified as a novel fusion in a child transformed to t-AML after successful treatment of APL. This study emphasized that clinical monitoring with an integrated laboratory approach is essential for the diagnosis and treatment of t-AML.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Antineoplastic Agents therapeutic use
Child, Preschool
Chromosomes, Human, Pair 11 genetics
Chromosomes, Human, Pair 12 genetics
Humans
Leukemia, Myeloid, Acute chemically induced
Leukemia, Promyelocytic, Acute genetics
Male
Oncogene Proteins, Fusion genetics
Translocation, Genetic
Whole Genome Sequencing
Antineoplastic Agents adverse effects
Histone-Lysine N-Methyltransferase genetics
Leukemia, Myeloid, Acute genetics
Leukemia, Promyelocytic, Acute drug therapy
Myeloid-Lymphoid Leukemia Protein genetics
Proton-Translocating ATPases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2744
- Volume :
- 60
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecular carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 34236108
- Full Text :
- https://doi.org/10.1002/mc.23333