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How can polyreactive antibodies conquer rapidly evolving viruses?
- Source :
-
Trends in immunology [Trends Immunol] 2021 Aug; Vol. 42 (8), pp. 654-657. Date of Electronic Publication: 2021 Jul 07. - Publication Year :
- 2021
-
Abstract
- Broadly neutralizing antibodies against rapidly evolving viruses (e.g., HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly evolving viruses. We propose that polyreactivity contributes to toleration of viral variants and shortens the time for generating neutralizing antibodies.<br />Competing Interests: Declaration of interests No interests are declared.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34246558
- Full Text :
- https://doi.org/10.1016/j.it.2021.06.008