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Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2021 Sep; Vol. 162 (3), pp. 555-559. Date of Electronic Publication: 2021 Jul 10. - Publication Year :
- 2021
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Abstract
- Objectives: Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.<br />Methods: Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology.<br />Results: A total of 1,704,055 cervical screening tests from 681,440 women aged 21-64 years in the state of New Mexico were identified. The proportion of screening tests which were co-tests rose from 5.6% in 2008 to 84.3% in 2019 among women aged 30-64 years with a marked change from the near exclusive use of the Hybrid Capture II HPV test, (a signal amplified test method) to the use of target amplified HPV tests. The largest increases were seen between 2013 and 2015, reflecting the introduction and adoption of new clinical guidelines. Increases in co-testing were also seen in younger women.<br />Conclusions: Co-testing is now well established in women aged 30-64 years, but smaller increases have also been seen at younger ages, although this is not currently recommended. The impact of co-testing on cervical disease outcomes and number of colposcopies and biopsies in routine population settings remain important, especially in young women.<br />Competing Interests: Declaration of competing interest JC and CMW have received funds from grants, cooperative agreements or subcontracts related to cervical screening and triage through their respective institutions. JC reports personal fees from Hologic and grants from Becton Dickinson (BD), Qiagen and Gene First all outside the submitted work. CMW reports receiving reagents and equipment from Roche Molecular Systems, Roche/Ventana Medical Systems, Hologic and Genera Biosystems, research funding from Hologic all through her institution and outside of the submitted work, personal fees from BD. All other authors report no potential conflicts of interest.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Early Detection of Cancer statistics & numerical data
Female
Humans
Middle Aged
Papillomaviridae isolation & purification
Papillomavirus Infections epidemiology
Papillomavirus Infections pathology
Papillomavirus Infections virology
Precancerous Conditions epidemiology
Precancerous Conditions pathology
Precancerous Conditions virology
Registries
United States
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms virology
Young Adult
Cervix Uteri pathology
Cervix Uteri virology
Papillomavirus Infections diagnosis
Precancerous Conditions diagnosis
Uterine Cervical Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 162
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 34253387
- Full Text :
- https://doi.org/10.1016/j.ygyno.2021.06.029