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Monitoring intraocular proangiogenic and profibrotic cytokines within 7 days after adjunctive anti-vascular endothelial growth factor therapy for proliferative diabetic retinopathy.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2022 May; Vol. 100 (3), pp. e726-e736. Date of Electronic Publication: 2021 Jul 14. - Publication Year :
- 2022
-
Abstract
- Purpose: To monitor the intraocular proangiogenic and profibrotic cytokine profiles within 7 days after intravitreous injection of conbercept (IVC) for patients with proliferative diabetic retinopathy (PDR).<br />Methods: This prospective, randomized controlled, consecutive, comparative study included 157 eyes with PDR. Participant eyes underwent sham IVC or IVC and subsequent vitrectomy at days 2, 3, 4, 5, 6, 7 postinjection. The intraocular cytokines profiles were measured using beaded assay methods.<br />Results: After IVC, the vascular endothelial growth factor (VEGF)-A level in PDR vitreous decreased rapidly by approximately 10 times at day 2 (p = 0.00001) and kept at a low level at days 3, 4, 5, 6, 7 (p < 0.001, each compared with IVC-sham group). Similar tendency of the change in VEGF-A was observed in aqueous humour. The level of placenta growth factor (PIGF) in aqueous humour decreased 2 days after IVC whereas returned to baseline level after 5 days. The vitreous profibrotic cytokines, tissue growth factor (TGF)-β1, TGF-β2, TGF-β3 and connective tissue growth factor did not increase after IVC in each group.<br />Conclusion: We observed a remarkable and rapid decrease in intraocular VEGF-A, temporal decrease in PIGF from day 2 to day 4, increase in VEGF-C and VEGF-D from day 2 onwards, but no profibrotic switch in PDR eyes after IVC. The findings might suggest that ideal vitrectomy timing might be around 3 days after IVC.<br /> (© 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Subjects :
- Cytokines metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intravitreal Injections
Placenta Growth Factor
Prospective Studies
Vascular Endothelial Growth Factor A metabolism
Vitrectomy methods
Diabetes Mellitus
Diabetic Retinopathy diagnosis
Diabetic Retinopathy drug therapy
Diabetic Retinopathy metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 100
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 34260829
- Full Text :
- https://doi.org/10.1111/aos.14957