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Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study).
- Source :
-
Molecular nutrition & food research [Mol Nutr Food Res] 2021 Sep; Vol. 65 (17), pp. e2001175. Date of Electronic Publication: 2021 Aug 02. - Publication Year :
- 2021
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Abstract
- Scope: The aim of the present work is to determine new biomarkers of the biological effects of hesperidin in orange juice (OJ) applying a non-targeted metabolomics approach validated by targeted metabolomics analyses of compliance biomarkers.<br />Methods and Results: Plasma/serum and urine targeted (HPLC-MS/MS) and untargeted ( <superscript>1</superscript> H-NMR) metabolomics signatures are explored in a subsample with pre- and stage-1 hypertension subjects of the CITRUS study (N = 159). Volunteers received 500 mL day <superscript>-1</superscript> of control drink, OJ, or hesperidin-enriched OJ (EOJ) for 12-weeks. A 6-h postprandrial study is performed at baseline. Targeted analyses reveals plasma and urine hesperetin 7-O-β-d-glucuronide as the only metabolite differing between OJ and EOJ groups after 12-weeks consumption, and in urine is correlated with a decreased systolic blood pressure level. The non-targeted approach shows that after single dose and 12-weeks consumption of OJ and EOJ change several metabolites related with an anti-inflammatory and antioxidant actions, lower blood pressure levels and uremic toxins.<br />Conclusions: Hesperetin 7-O-β-d-glucuronide can be a candidate marker for distinguishing between the consumption of different hesperidin doses at 12-weeks consumption as well as a potential agent mediating blood pressure reduction. Moreover, changes in different endogenous metabolites can explain the mechanisms of action and the biological effects of hesperidin consumption.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Adult
Biomarkers blood
Biomarkers urine
Female
Fruit and Vegetable Juices
Glucuronides blood
Glucuronides urine
Hesperidin analogs & derivatives
Hesperidin blood
Hesperidin metabolism
Hesperidin urine
Humans
Hypertension metabolism
Male
Metabolomics methods
Middle Aged
Postprandial Period
Citrus sinensis chemistry
Hesperidin pharmacology
Hypertension diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1613-4133
- Volume :
- 65
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Molecular nutrition & food research
- Publication Type :
- Academic Journal
- Accession number :
- 34272817
- Full Text :
- https://doi.org/10.1002/mnfr.202001175