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Protective effects of chitosan and chitosan oligosaccharide against oxidative damage in liver tissue of rats with fluorine poisoning.
- Source :
-
Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2021 Jan; Vol. 34 (1(Special)), pp. 373-379. - Publication Year :
- 2021
-
Abstract
- Fluorine toxicity has negative effects on soft tissue besides skeletal and dental tissues. In the present study, we have investigated the protective effect of chitosan (CS) and chitosan oligosaccharide (COS) on liver tissue of fluorine-intoxicated rats taking the antioxidant characteristics of chitosan and its derivatives into consideration. In this study, 42 male Wistar albino rats were randomly selected to determine the control and experimental fluorosis groups. Our study lasted for 12 weeks. As a consequence of the study, MDA significantly increased in the liver tissue of NaF group while some antioxidant values significantly decreased. It was detected that serum AST and LDH levels increased significantly while ALB and TP values significantly decreased in NaF group. The degenerations were identified in the liver histopathology of all fluoride-treated groups. We have concluded according to the results that chitosan oligosaccharide can be more effective compared with chitosan.
- Subjects :
- Animals
Aspartate Aminotransferases drug effects
Aspartate Aminotransferases metabolism
Blood Proteins drug effects
Blood Proteins metabolism
Chitosan analogs & derivatives
Glutathione drug effects
Glutathione metabolism
Glutathione Peroxidase drug effects
Glutathione Peroxidase metabolism
L-Lactate Dehydrogenase drug effects
L-Lactate Dehydrogenase metabolism
Liver metabolism
Liver pathology
Male
Malondialdehyde metabolism
Oligosaccharides pharmacology
Rats
Rats, Wistar
Serum Albumin drug effects
Serum Albumin metabolism
Superoxide Dismutase drug effects
Superoxide Dismutase metabolism
Antioxidants pharmacology
Chitosan pharmacology
Liver drug effects
Oxidative Stress drug effects
Sodium Fluoride toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1011-601X
- Volume :
- 34
- Issue :
- 1(Special)
- Database :
- MEDLINE
- Journal :
- Pakistan journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34275782