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Concomitant Mitral Regurgitation in Severe Aortic Stenosis - A Report From the CURRENT AS Registry.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2022 Feb 25; Vol. 86 (3), pp. 427-437. Date of Electronic Publication: 2021 Jul 16. - Publication Year :
- 2022
-
Abstract
- Background: The clinical significance of concomitant mitral regurgitation (MR) has not been well addressed in patients with severe aortic stenosis (AS).<br />Methods and results: We analyzed 3,815 patients from a retrospective multicenter registry of severe AS in Japan (CURRENT AS registry). We compared the clinical outcomes between patients with moderate/severe MR and with none/mild MR according to the initial treatment strategy (initial aortic valve replacement [AVR] or conservative strategy). The primary outcome measure was a composite of aortic valve-related death or heart failure hospitalization. At baseline, moderate/severe MR was present in 227/1,197 (19%) patients with initial AVR strategy and in 536/2,618 (20%) patients with a conservative strategy. The crude cumulative 5-year incidence of the primary outcome measure was significantly higher in patients with moderate/severe MR than in those with none/mild MR, regardless of the initial treatment strategy (25.2% vs. 14.4%, P<0.001 in the initial AVR strategy, and 63.3% vs. 40.7%, P<0.001 in the conservative strategy). After adjusting confounders, moderate/severe MR was not independently associated with higher risk for the primary outcome measure in the initial AVR strategy (hazard ratio [HR] 1.11, 95% confidence interval [CI] 0.67-1.83, P=0.69), and in the conservative strategy (HR 1.13, 95% CI 0.93-1.37, P=0.22).<br />Conclusions: Concomitant moderate/severe MR was not independently associated with higher risk for the primary outcome measure regardless of the initial treatment strategy.
- Subjects :
- Aortic Valve surgery
Humans
Registries
Retrospective Studies
Severity of Illness Index
Treatment Outcome
Aortic Valve Stenosis complications
Aortic Valve Stenosis diagnostic imaging
Aortic Valve Stenosis surgery
Heart Valve Prosthesis Implantation adverse effects
Mitral Valve Insufficiency complications
Mitral Valve Insufficiency diagnostic imaging
Mitral Valve Insufficiency epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-4820
- Volume :
- 86
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 34275976
- Full Text :
- https://doi.org/10.1253/circj.CJ-21-0054