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Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients.
- Source :
-
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Jul 21; Vol. 16 (1), pp. 325. Date of Electronic Publication: 2021 Jul 21. - Publication Year :
- 2021
-
Abstract
- Background: Patients with Prader-Willi syndrome (PWS) often have comorbidities, especially obesity, that may constitute a risk factor for severe forms of COVID-19. We aimed to assess prevalence and medical course of SARS-CoV-2 infection in children and adults with PWS. From November 2020 to January 2021, we performed a detailed medical survey on 342 adults and 305 children with PWS followed in the French reference center.<br />Results: We obtained responses from 288 adults (84%) and 239 children (78%). From March 2020 to January 2021, 38 adults (13.2%) and 13 children (5.4%) with PWS had SARS-CoV-2 infection. Mean age of adults was 34.1 ± 11.9 years and mean body mass index was 40.6 ± 12.7 kg/m <superscript>2</superscript> ; 82% had obesity and 37% had diabetes. Only 3 children (23%) had obesity and none had diabetes. Similar to the general population, the most frequent symptoms of COVID-19 were asthenia, fever, cough, headache and shortness of breath. All patients had a favorable outcome.<br />Conclusion: PWS itself is not a risk factor for severe COVID-19 in children and adults. On the contrary, evolution of SARS-CoV-2 infection in adults with PWS seems more favorable than expected, given their comorbidities.<br /> (© 2021. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1750-1172
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Orphanet journal of rare diseases
- Publication Type :
- Academic Journal
- Accession number :
- 34289876
- Full Text :
- https://doi.org/10.1186/s13023-021-01949-4