Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile.

Authors :: Hickman RA
Gionco JT
Faust PL
Miller ML
Bruce J
Page-Wilson G
Rosenblum MK
Asa SL
Source :: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Feb; Vol. 48 (2), pp. e12754. Date of Electronic Publication: 2021 Aug 09.
Publication Year :: 2022
Abstract: We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.<br /> (© 2021 British Neuropathological Society.)

Subjects :: ACTH-Secreting Pituitary Adenoma genetics
ACTH-Secreting Pituitary Adenoma metabolism
Adult
Corticotrophs metabolism
Humans
Male
Pituitary Gland metabolism
Pituitary Neoplasms genetics
Pituitary Neoplasms metabolism
ACTH-Secreting Pituitary Adenoma pathology
Corticotrophs pathology
DNA Methylation
Pituitary Gland pathology
Pituitary Neoplasms pathology

Full Text Access

Tools