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Baricitinib prevents GvHD by increasing Tregs via JAK3 and treats established GvHD by promoting intestinal tissue repair via EGFR.
- Source :
-
Leukemia [Leukemia] 2022 Jan; Vol. 36 (1), pp. 292-295. Date of Electronic Publication: 2021 Jul 24. - Publication Year :
- 2022
- Subjects :
- Animals
ErbB Receptors genetics
Graft vs Host Disease immunology
Graft vs Host Disease pathology
Intestines injuries
Intestines pathology
Mice
Azetidines pharmacology
ErbB Receptors metabolism
Graft vs Host Disease prevention & control
Intestines drug effects
Janus Kinase 3 antagonists & inhibitors
Purines pharmacology
Pyrazoles pharmacology
Sulfonamides pharmacology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5551
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Leukemia
- Publication Type :
- Academic Journal
- Accession number :
- 34304247
- Full Text :
- https://doi.org/10.1038/s41375-021-01360-9