Back to Search
Start Over
Comparing data-driven and hypothesis-driven MRI-based predictors of cognitive impairment in individuals from the Atherosclerosis Risk in Communities (ARIC) study.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Apr; Vol. 18 (4), pp. 561-571. Date of Electronic Publication: 2021 Jul 26. - Publication Year :
- 2022
-
Abstract
- Introduction: A data-driven index of dementia risk based on magnetic resonance imaging (MRI), the Alzheimer's Disease Pattern Similarity (AD-PS) score, was estimated for participants in the Atherosclerosis Risk in Communities (ARIC) study.<br />Methods: AD-PS scores were generated for 839 cognitively non-impaired individuals with a mean follow-up of 4.86 years. The scores and a hypothesis-driven volumetric measure based on several brain regions susceptible to AD were compared as predictors of incident cognitive impairment in different settings.<br />Results: Logistic regression analyses suggest the data-driven AD-PS scores to be more predictive of incident cognitive impairment than its counterpart. Both biomarkers were more predictive of incident cognitive impairment in participants who were White, female, and apolipoprotein E gene (APOE) ε4 carriers. Random forest analyses including predictors from different domains ranked the AD-PS scores as the most relevant MRI predictor of cognitive impairment.<br />Conclusions: Overall, the AD-PS scores were the stronger MRI-derived predictors of incident cognitive impairment in cognitively non-impaired individuals.<br /> (© 2021 the Alzheimer's Association.)
- Subjects :
- Apolipoprotein E4 genetics
Brain diagnostic imaging
Female
Humans
Magnetic Resonance Imaging
Alzheimer Disease diagnostic imaging
Alzheimer Disease epidemiology
Alzheimer Disease genetics
Atherosclerosis diagnostic imaging
Atherosclerosis epidemiology
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction epidemiology
Cognitive Dysfunction genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 34310039
- Full Text :
- https://doi.org/10.1002/alz.12427