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Efficacy and expenses of succimer vs. d-penicillamine plus garlic in the treatment of lead poisoning: a retrospective cross-sectional study.
- Source :
-
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2021 Dec; Vol. 29 (2), pp. 477-481. Date of Electronic Publication: 2021 Jul 27. - Publication Year :
- 2021
-
Abstract
- Purpose: Lead Poisoning is a major health problem in Iran. We aimed to compare efficacy of a standard regimen (Succimer) with that of a low-priced combination of D-penicillamine and Garlic in outpatients with lead poisoning.<br />Methods: In this retrospective cross-sectional study, year-long clinical files of outpatients with lead poisoning in two referral toxicology clinics in Mashhad, Iran were reviewed. A total of 79 patients (all men), received either Succimer or a combination of D-penicillamen plus garlic (DPN + Gar), for 19 and 30 days, respectively. Clinical and laboratory data, including blood lead level (BLL), were analyzed and treatment expanses were compared between the two regimens.<br />Results: Of 79 male patients, 42 were treated by DPN + Gar and 37 received Succimer. Mean BLL of DPN + Gar group before treatment (965.73 ± 62.54 µg/L) was higher than that of the Succimer group (827.59 ± 24.41) (p < 0.001). After treatment, BLL in both groups significantly reduced to 365.52 ± 27.61 µg/L and 337.44 ± 26.34 µg/L, respectively (p < 0.001). The price of a 19-day treatment with Succimer was approximately 28.6 times higher than a one-month course of treatment with garlic plus DPN. None of the treatments caused serious side effects in the patients.<br />Conclusion: Combination therapy with DPN + Gar is as effective as Succimer in Pb poisoning, while treatment with Succimer is significantly more expensive.<br /> (© 2021. Springer Nature Switzerland AG.)
- Subjects :
- Adult
Antidotes economics
Cost-Benefit Analysis
Cross-Sectional Studies
Drug Therapy, Combination
Humans
Iran
Lead blood
Lead Poisoning blood
Male
Penicillamine economics
Phytochemicals economics
Retrospective Studies
Succimer economics
Treatment Outcome
Antidotes administration & dosage
Garlic chemistry
Lead Poisoning drug therapy
Penicillamine administration & dosage
Phytochemicals administration & dosage
Succimer administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2008-2231
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34313939
- Full Text :
- https://doi.org/10.1007/s40199-021-00407-7