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Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Aug 25; Vol. 57 (66), pp. 8174-8177. Date of Electronic Publication: 2021 Jul 27. - Publication Year :
- 2021
-
Abstract
- A nitroreductase (NTR)-activated NIR-II fluorescence probe for tumor imaging is reported. The probe can emit fluorescence in the range of 900-1300 nm, and target hypoxic tumors with NTR overexpression, thus allowing for accurate delineation of tumor margins through deep penetration.
- Subjects :
- A549 Cells
Adenocarcinoma, Bronchiolo-Alveolar metabolism
Animals
Fluorescent Dyes metabolism
Humans
Infrared Rays
Lung Neoplasms metabolism
Mice
Molecular Structure
Neoplasms, Experimental diagnostic imaging
Neoplasms, Experimental metabolism
Nitroreductases chemistry
Spectrometry, Fluorescence
Adenocarcinoma, Bronchiolo-Alveolar diagnostic imaging
Fluorescent Dyes chemistry
Lung Neoplasms diagnostic imaging
Nitroreductases metabolism
Optical Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 66
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34318817
- Full Text :
- https://doi.org/10.1039/d1cc03232a