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Aggravation of functional mitral regurgitation on left ventricle stiffness in type 2 diabetes mellitus patients evaluated by CMR tissue tracking.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Jul 31; Vol. 20 (1), pp. 158. Date of Electronic Publication: 2021 Jul 31. - Publication Year :
- 2021
-
Abstract
- Background: Functional mitral regurgitation (FMR) is one of the most common heart valve diseases in diabetes and may increase left ventricular (LV) preload and aggravate myocardial stiffness. This study aimed to investigate the aggravation of FMR on the deterioration of LV strain in type 2 diabetes mellitus (T2DM) patients and explore the independent indicators of LV peak strain (PS).<br />Materials and Methods: In total, 157 T2DM patients (59 patients with and 98 without FMR) and 52 age- and sex-matched healthy control volunteers were included and underwent cardiac magnetic resonance examination. T2DM with FMR patients were divided into T2DM patients with mild (n = 21), moderate (n = 19) and severe (n = 19) regurgitation. LV function and global strain parameters were compared among groups. Multivariate analysis was used to identify the independent indicators of LV PS.<br />Results: The T2DM with FMR had lower LV strain parameters in radial, circumferential and longitudinal direction than both the normal and the T2DM without FMR (all P < 0.05). The mild had mainly decreased peak diastolic strain rate (PDSR) compared to the normal. The moderate had decreased peak systolic strain rate (PSSR) compared to the normal and PDSR compared to the mild and the normal. The severe FMR group had decreased PDSR and PSSR compared to the mild and the normal (all P < 0.05). Multiple linear regression showed that the regurgitation degree was independent associated with radial (β = - 0.272), circumferential (β = - 0.412) and longitudinal (β = - 0.347) PS; the months with diabetes was independently associated with radial (β = - 0.299) and longitudinal (β = - 0.347) PS in T2DM with FMR.<br />Conclusion: FMR may aggravate the deterioration of LV stiffness in T2DM patients, resulting in decline of LV strain and function. The regurgitation degree and months with diabetes were independently correlated with LV global PS in T2DM with FMR.<br /> (© 2021. The Author(s).)
- Subjects :
- Aged
Diabetes Mellitus, Type 2 diagnosis
Diabetic Cardiomyopathies etiology
Diabetic Cardiomyopathies physiopathology
Disease Progression
Female
Humans
Male
Middle Aged
Mitral Valve physiopathology
Mitral Valve Insufficiency etiology
Mitral Valve Insufficiency physiopathology
Predictive Value of Tests
Prognosis
Time Factors
Ventricular Dysfunction, Left etiology
Ventricular Dysfunction, Left physiopathology
Diabetes Mellitus, Type 2 complications
Diabetic Cardiomyopathies diagnostic imaging
Magnetic Resonance Imaging
Mitral Valve diagnostic imaging
Mitral Valve Insufficiency diagnostic imaging
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Function, Left
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 34332579
- Full Text :
- https://doi.org/10.1186/s12933-021-01354-y