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Interventional and Surgical Treatments for Pulmonary Arterial Hypertension.

Authors :
Stącel T
Latos M
Urlik M
Nęcki M
Antończyk R
Hrapkowicz T
Kurzyna M
Ochman M
Source :
Journal of clinical medicine [J Clin Med] 2021 Jul 28; Vol. 10 (15). Date of Electronic Publication: 2021 Jul 28.
Publication Year :
2021

Abstract

Despite significant advancements in pharmacological treatment, interventional and surgical options are still viable treatments for patients with pulmonary arterial hypertension (PAH), particularly idiopathic PAH. Herein, we review the interventional and surgical treatments for PAH. Atrial septostomy and the Potts shunt can be useful bridging tools for lung transplantation (Ltx), which remains the final surgical treatment among patients who are refractory to any other kind of therapy. Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) remains the ultimate bridging therapy for patients with severe PAH. More importantly, VA-ECMO plays a crucial role during Ltx and provides necessary left ventricular conditioning during the initial postoperative period. Pulmonary denervation may potentially be a new way to ensure better transplant-free survival among patients with the aforementioned disease. However, high-quality randomized controlled trials are needed. As established, obtaining the Eisenmenger physiology among patients with severe pulmonary hypertension by creating artificial defects is associated with improved survival. However, right-to-left shunting may be harmful after Ltx. Closure of the artificially created defects may carry some risk associated with cardiac surgery, especially among patients with Potts shunts. In conclusion, PAH requires an interdisciplinary approach using pharmacological, interventional, and surgical modalities.

Details

Language :
English
ISSN :
2077-0383
Volume :
10
Issue :
15
Database :
MEDLINE
Journal :
Journal of clinical medicine
Publication Type :
Academic Journal
Accession number :
34362109
Full Text :
https://doi.org/10.3390/jcm10153326