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[Differential Diagnosis of Three Commonest Deletion β-Thalassemia in Chinese].
- Source :
-
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Aug; Vol. 29 (4), pp. 1247-1250. - Publication Year :
- 2021
-
Abstract
- Objective: To analyze the hematological characteristics of Chinese <superscript>G</superscript> γ <superscript>+</superscript> ( <superscript>A</superscript> γδβ) <superscript>0</superscript> -thalassemia,SEA-HPFH and Taiwan type β-thalassemia.<br />Methods: Hemoglobin electrophoresis and blood routine test were used to analyze the hematological indexes of all peripheral blood samples,PCR-Flow fluorescent hybridization and Gap-PCR were used to detect the globin gene mutations and the data were analyzed statistically.<br />Results: The 3 types of deletion β- Thalassemia patients were showed as hypochromic small cell anemia. The MCH and MCV values of Taiwan type β-thalassemia patients were the lowest. The results of hemoglobin electrophoresis showed that the increasing of HbF was found in all of the 3 types. Except for the decreasing of Hb A2 in Chinese <superscript>G</superscript> γ <superscript>+</superscript> ( <superscript>A</superscript> γδβ) <superscript>0</superscript> -thalassemia,the levels of Hb A2 in the other two deletion β-thalassemia patients were significantly increased. Except for Hb, there were significant differences in MCV, MCH, Hb A2 and HbF between Chinese <superscript>G</superscript> γ <superscript>+</superscript> ( <superscript>A</superscript> γδβ) <superscript>0</superscript> -thalassemia and SEA-HPFH(P<0.001).<br />Conclusion: Through analyze the hematological characteristics, it can be provide that the guidance for the differential diagnosis and genetic consultation of the three commonest deletion β-thalassemia in Chinese.
Details
- Language :
- Chinese
- ISSN :
- 1009-2137
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo shi yan xue ye xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 34362510
- Full Text :
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2021.04.035