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Antitumor activity of lipopolysaccharide and radio-detoxified lipopolysaccharide of Vibrio parahaemolyticus.

Authors :
Bandekar JR
Nerkar DP
Source :
Microbiology and immunology [Microbiol Immunol] 1987; Vol. 31 (7), pp. 675-81.
Publication Year :
1987

Abstract

The antitumor activity of lipopolysaccharide (LPS) and radio-detoxified LPS of Vibrio parahaemolyticus was tested against S180 cells in Swiss mice. The toxicity of the LPS was 200 times less than that of Salmonella typhimurium LPS. The V. parahaemolyticus LPS could be detoxified by exposure to gamma radiation. Both LPS and the irradiated LPS exhibited antitumor activity, though the irradiated LPS was less effective than the native LPS. These observations indicated that exposure to gamma radiation caused significant detoxification of V. parahaemolyticus LPS and the detoxified LPS still possessed considerable antitumor activity.

Details

Language :
English
ISSN :
0385-5600
Volume :
31
Issue :
7
Database :
MEDLINE
Journal :
Microbiology and immunology
Publication Type :
Academic Journal
Accession number :
3437829
Full Text :
https://doi.org/10.1111/j.1348-0421.1987.tb03128.x