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Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes.
- Source :
-
Science (New York, N.Y.) [Science] 2021 Aug 13; Vol. 373 (6556), pp. 774-779. - Publication Year :
- 2021
-
Abstract
- The oomycete Phytophthora infestans is a damaging crop pathogen and a model organism to study plant-pathogen interactions. We report the discovery of a family of copper-dependent lytic polysaccharide monooxygenases (LPMOs) in plant pathogenic oomycetes and its role in plant infection by P. infestans We show that LPMO-encoding genes are up-regulated early during infection and that the secreted enzymes oxidatively cleave the backbone of pectin, a charged polysaccharide in the plant cell wall. The crystal structure of the most abundant of these LPMOs sheds light on its ability to recognize and degrade pectin, and silencing the encoding gene in P. infestans inhibits infection of potato, indicating a role in host penetration. The identification of LPMOs as virulence factors in pathogenic oomycetes opens up opportunities in crop protection and food security.<br /> (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Subjects :
- Copper
Mixed Function Oxygenases chemistry
Mixed Function Oxygenases genetics
Models, Molecular
Oxidation-Reduction
Phytophthora infestans genetics
Phytophthora infestans pathogenicity
Plant Leaves parasitology
Polysaccharides metabolism
Protein Conformation
Protein Domains
Virulence Factors chemistry
Virulence Factors genetics
Virulence Factors metabolism
Solanum lycopersicum parasitology
Mixed Function Oxygenases metabolism
Pectins metabolism
Phytophthora infestans enzymology
Plant Diseases parasitology
Solanum tuberosum parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 373
- Issue :
- 6556
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 34385392
- Full Text :
- https://doi.org/10.1126/science.abj1342