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The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women.

Authors :
Haidari F
Mohammadshahi M
Zarei M
Haghighizadeh MH
Mirzaee F
Source :
Clinical nutrition research [Clin Nutr Res] 2021 Jul 22; Vol. 10 (3), pp. 230-242. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Publication Year :
2021

Abstract

Obesity has reached epidemic proportions globally. Among several methods for treating obesity, the use of dietary supplements is common recently. One supplement that can help in this regard might be vitamin B6 in high doses. The objective of this study was to evaluate the effect of pyridoxine hydrochloride supplementation on anthropometric indices, body composition, visceral adiposity index (VAI), and metabolic status in obese and overweight women. In this randomized controlled clinical trial, 44 obese and overweight women aged 18-50 years were selected and divided randomly into 2 groups: an intervention group (receiving 80 mg pyridoxine hydrochloride supplement for 8 weeks) and a control group (receiving placebo for 8 weeks). In the pyridoxine hydrochloride group, weight (p = 0.03), body mass index (p = 0.023), fat mass (p = 0.003), waist circumference (p = 0.005), VAI (p = 0.001), fasting insulin, insulin resistance (homeostasis model assessment of insulin resistance; HOMA-IR), total cholesterol, low-density lipoprotein, triglycerides (TG) and leptin (p < 0.001) decreased whereas adiponectin (p < 0.001) increased in comparison to the baseline values. There was a significant difference in fat mass, VAI, fasting insulin, HOMA-IR, and TG between pyridoxine hydrochloride and control groups following intervention in adjusted models (p < 0.05). The findings suggest that vitamin B6 supplementation may be effective in reducing BMI and improving body composition and biochemical factors associated with obesity.<br />Trial Registration: Iranian Registry of Clinical Trials Identifier: IRCT20181002041206N1.<br />Competing Interests: Conflict of Interest: The authors declare that they have no competing interests.<br /> (Copyright © 2021. The Korean Society of Clinical Nutrition.)

Details

Language :
English
ISSN :
2287-3732
Volume :
10
Issue :
3
Database :
MEDLINE
Journal :
Clinical nutrition research
Publication Type :
Academic Journal
Accession number :
34386442
Full Text :
https://doi.org/10.7762/cnr.2021.10.3.230