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Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana.
- Source :
-
International journal of environmental health research [Int J Environ Health Res] 2022 Nov; Vol. 32 (11), pp. 2406-2424. Date of Electronic Publication: 2021 Aug 17. - Publication Year :
- 2022
-
Abstract
- This study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste workers serving as controls. Long interspersed nucleotide repetitive elements-1 (LINE-1) was measured by pyrosequencing. Personal PM <subscript>2.5</subscript> and PM <subscript>10</subscript> were measured over a 4-hour work-shift using real-time particulate monitors incorporated into a backpack . Linear regression models were used to assess the association between PM and LINE-1 DNA methylation. The concentrations of PM <subscript>2.5</subscript> and PM <subscript>10</subscript> were significantly higher among the e-waste workers than the controls (77.32 vs 34.88, p < 0.001 and 210.21 vs 121.92, p < 0.001 , respectively). PM <subscript>2.5</subscript> exposure was associated with increased LINE-1 CpG2 DNA methylation (β = 0.003; 95% CI; 0.001, 0.006; p = 0.022) but not with the average of all 4 CpG sites of LINE-1. In summary, high levels of PM <subscript>2.5</subscript> exposure was associated with increased levels of global DNA methylation in a site-specific manner.
Details
- Language :
- English
- ISSN :
- 1369-1619
- Volume :
- 32
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of environmental health research
- Publication Type :
- Academic Journal
- Accession number :
- 34404291
- Full Text :
- https://doi.org/10.1080/09603123.2021.1969007