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Multicenter, phase II study of response-adapted lenalidomide-based therapy for transplant-ineligible patients with newly diagnosed multiple myeloma without high-risk features.
- Source :
-
Current problems in cancer [Curr Probl Cancer] 2022 Feb; Vol. 46 (1), pp. 100788. Date of Electronic Publication: 2021 Aug 21. - Publication Year :
- 2022
-
Abstract
- Lenalidomide and low-dose dexamethasone (Rd) are a standard treatment for older adults with multiple myeloma (MM). Lenalidomide monotherapy has rarely been evaluated for newly diagnosed transplant-ineligible MM patients. This multicenter phase II trial evaluated a response-adapted strategy for elderly patients with newly diagnosed MM without high-risk features. Patients were administered single-agent lenalidomide for the first 21 days of two 28-day cycles. Patients with progressive disease received Rd. The primary endpoint was progression-free survival using the uniform response assessment from the International Myeloma Working Group . Of the 34 enrolled patients, 28 were included in the efficacy analysis. The overall response rate (ORR, ≥ partial response [PR]) to single-agent lenalidomide or lenalidomide plus prednisone was 64.3%. Ten patients received Rd after disease progression, with an Rd ORR of 70%. The ORR of response-adapted lenalidomide-based therapy was 75%. After the median follow-up of 35.6 months, the median progression-free survival was 33.5 months (95% confidence interval [CI], 16.9-50.2), and the median overall survival was 51.8 months (95% CI, 22.0-81.6). The most common adverse event was neutropenia (46.7%), and 17 patients (56.7%) experienced infection including pneumonia. Response-adapted lenalidomide-based therapy was feasible in newly diagnosed, transplant-ineligible MM patients without high-risk features.<br />Competing Interests: Conflict of interest RB received research funding from Celgene, Karyopharm, Abbvie, Merck, and Sanofi; is on the advisory boards of Celgene, Karyopharm, and Sanofi; and has received honoraria from GSK. The other authors declare that they have no conflict of interest.<br /> (Copyright © 2021. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1535-6345
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current problems in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 34454742
- Full Text :
- https://doi.org/10.1016/j.currproblcancer.2021.100788