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Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells.
- Source :
-
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Oct; Vol. 87, pp. 103735. Date of Electronic Publication: 2021 Aug 27. - Publication Year :
- 2021
-
Abstract
- 3-chloropropane-1,2-diol (3-MCPD) and its toxic metabolite glycidol were classified by the International Agency for Research on Cancer (IARC) as belonging to group 2B and 2A for humans. This study aimed to determine the sub-acute toxicity of these agents. Rats were exposed to 3-MCPD at 0.87 and 10 mg/kg/bw and glycidol (2,4 and 37,5 mg/kg/bw) for 90 days. miR-21 gene expression levels significantly decreased in all group's cerebellar tissues compared with control. Exposure to 10 mg/kg/bw 3-MCPD showed significant increases in PTEN in brain as compared to control group. The Akt gen expressions were significantly decreased in 3-MCPD and glycidol groups when compared to control group brains. Additionally, Caspase 3 and AIF immunopositivity significantly increased in 3-MCPD high dose and glycidol high dose groups in cerebellum granular layers compared to control. The results of the present study conclude that 3-MCPD and glycidol can induce apoptosis in rat brain tissue.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Apoptosis Inducing Factor metabolism
Brain cytology
Brain metabolism
Caspase 3 metabolism
Male
MicroRNAs
PTEN Phosphohydrolase genetics
Proto-Oncogene Proteins c-akt genetics
Rats, Wistar
Rats
Apoptosis drug effects
Brain drug effects
Chemosterilants toxicity
Epoxy Compounds toxicity
Propanols toxicity
alpha-Chlorohydrin toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7077
- Volume :
- 87
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34461274
- Full Text :
- https://doi.org/10.1016/j.etap.2021.103735