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Polyarthralgia and Myalgia Syndrome after ChAdOx1 nCOV-19 Vaccination.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2021 Aug 30; Vol. 36 (34), pp. e245. Date of Electronic Publication: 2021 Aug 30. - Publication Year :
- 2021
-
Abstract
- Since February 26, 2021, when vaccination against coronavirus disease 2019 (COVID-19) began in South Korea, patients who visited the Korea University Guro Hospital with suspected adverse events after COVID-19 vaccination were monitored actively with interest. We encountered five unusual cases of polyarthralgia and myalgia syndrome in patients who received the ChAdOx1 nCOV-19 (AstraZeneca) vaccine. The patients (median age 67 years) were not previously diagnosed with arthropathy and rheumatologic diseases. They developed fever, myalgia, joint pain, and swelling three to seven days after vaccination. The symptoms persisted for up to 47 days despite antipyretic treatment. Arthralgia occurred in multiple joints, including small and large joints. A whole-body Technetium-99m methylene diphosphonate bone scan revealed unusual uptakes in the affected joints. Non-steroidal anti-inflammatory drugs with or without prednisolone relieved the symptoms of all patients. Further monitoring is required to clarify the long-term prognosis of this syndrome.<br />Competing Interests: The authors have no potential conflicts of interest to disclose.<br /> (© 2021 The Korean Academy of Medical Sciences.)
- Subjects :
- Adult
Aged
Antipsychotic Agents therapeutic use
Arthralgia drug therapy
COVID-19 virology
ChAdOx1 nCoV-19
Female
Humans
Joints diagnostic imaging
Joints pathology
Myalgia drug therapy
Republic of Korea
SARS-CoV-2 isolation & purification
Tomography, X-Ray Computed
Arthralgia etiology
COVID-19 prevention & control
COVID-19 Vaccines administration & dosage
Myalgia etiology
Vaccination adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 36
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 34463066
- Full Text :
- https://doi.org/10.3346/jkms.2021.36.e245