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Longitudinal Assessment of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2021 Sep 01; Vol. 224 (5), pp. 754-763. - Publication Year :
- 2021
-
Abstract
- Background: There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.<br />Methods: We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/nonpneumonic (n = 42), and pneumonic (n = 41) patients.<br />Results: The anti-SARS-CoV-2 immunoglobulin class G and neutralizing antibody (NAb) titers lasted until 6 months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding, and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. Severe acute respiratory syndrome coronavirus 2-specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity.<br />Conclusions: In conclusion, most (>85%) patients carry NAb until 6 months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19.<br /> (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
COVID-19 diagnosis
COVID-19 virology
Female
Humans
Immunity, Cellular
Immunity, Humoral
Immunoglobulin G immunology
Longitudinal Studies
Male
Middle Aged
Prospective Studies
T-Lymphocytes immunology
Virus Shedding
COVID-19 immunology
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 224
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 34467985
- Full Text :
- https://doi.org/10.1093/infdis/jiab124