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Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2021; Vol. 44 (9), pp. 1254-1262. - Publication Year :
- 2021
-
Abstract
- Betanin, a bioactive ingredient mostly isolated from beetroots, exhibits a protective effect against cardiovascular diseases. However, its effects on abdominal aortic aneurysm (AAA) have not been elucidated. In this study, an AAA model was constructed by infusion of porcine pancreatic elastase in C57BL/6 mice. Mice were then administered with betanin or saline intragastrically once daily for 14 d. Our results showed that treatment with betanin remarkably limited AAA enlargement and mitigated the infiltration of inflammatory cells in the adventitia. The increased expression of proinflammatory cytokines and matrix metalloproteinases (MMPs) was also significantly alleviated following betanin treatment. Furthermore, betanin suppressed the activation of toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) signaling in the aortic wall, and downregulated the levels of tissue-reactive oxygen species as well as circulating 8-isoprostane by stimulating the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Taken together, these data suggest that betanin may attenuate AAA progression and may be used as a therapeutic drug against AAA.
- Subjects :
- Animals
Aorta, Abdominal drug effects
Aorta, Abdominal pathology
Aortic Aneurysm, Abdominal chemically induced
Aortic Aneurysm, Abdominal pathology
Betacyanins therapeutic use
Disease Models, Animal
Heme Oxygenase-1 metabolism
Humans
Male
Membrane Proteins metabolism
Mice
NF-E2-Related Factor 2 metabolism
NF-kappa B metabolism
Pancreatic Elastase administration & dosage
Pancreatic Elastase toxicity
Swine
Toll-Like Receptor 4
Aortic Aneurysm, Abdominal drug therapy
Betacyanins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 44
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 34471054
- Full Text :
- https://doi.org/10.1248/bpb.b21-00042