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The role of retinoic acid in the commitment to meiosis.

Authors :
Gewiss RL
Schleif MC
Griswold MD
Source :
Asian journal of andrology [Asian J Androl] 2021 Nov-Dec; Vol. 23 (6), pp. 549-554.
Publication Year :
2021

Abstract

Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.<br />Competing Interests: None

Details

Language :
English
ISSN :
1745-7262
Volume :
23
Issue :
6
Database :
MEDLINE
Journal :
Asian journal of andrology
Publication Type :
Academic Journal
Accession number :
34472453
Full Text :
https://doi.org/10.4103/aja202156