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The Chemistry behind ThiC Rearrangement.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2022 Jan 05; Vol. 23 (1), pp. e202100385. Date of Electronic Publication: 2021 Sep 21. - Publication Year :
- 2022
-
Abstract
- Thiamine (vitamin B1) is crucial for life and plays a central role in metabolism. It contains thiazole and pyrimidine moieties that are constructed independently and then assembled together to generate thiamine phosphate. The study of the thiazole moiety is relatively clear, but deciphering the mechanistic enzymology of thiamine pyrimidine is more difficult. This review aims to summarize the recent research progress on ThiC rearrangement, mainly including the mechanism, related enzymes, and genes involved in the rearrangement.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Molecular Structure
Thiamine chemistry
Thiamine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 34494352
- Full Text :
- https://doi.org/10.1002/cbic.202100385