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Prevalence of Latent Tuberculosis Infection Among Healthy Young Children and Adolescents and a Two-step Approach for the Diagnosis of Tuberculosis Infection in Chengdu, China.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2022 Jan 01; Vol. 41 (1), pp. 6-11. - Publication Year :
- 2022
-
Abstract
- Background: China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tuberculosis infection in Chengdu, China.<br />Methods: Healthy preschool children and school-going children in Chengdu, Sichuan Province, were screened for LTBI using the tuberculin skin test (TST). Preschool children with TST ≥ 5 mm also underwent interferon-γ release assay (IGRA) to explore the threshold of this 2-step approach.<br />Results: In total, 5667 healthy young children and adolescents completed TST test between July 2020 and January 2021 and were included in the present analysis. The age of the participants ranged from 2.4 to 18 years (median 7.25 ± 4.514 years), of which 2093 (36.9%) were younger than 5 years. The overall prevalence of LTBI was 6.37% and 6.64% in children younger than 5 years old. Fourteen of the 341 preschool children with TST ≥5 mm were interferon-γ release assay positive, of which 4 showed a TST result of 5-10 mm, and 6 preschool children received preventive treatment for LTBI.<br />Conclusions: Healthy young children and adolescents should also be considered as important target populations for LTBI screening. TST can be recommended for first-line screening as part of a 2-step approach for LTBI screening using a positive threshold of 5 mm.<br />Competing Interests: The authors have no conflicts of interest to disclose.<br /> (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Adolescent
Child
Child, Preschool
China epidemiology
Clinical Laboratory Techniques standards
Female
Healthy Volunteers
Humans
Interferon-gamma Release Tests economics
Interferon-gamma Release Tests methods
Male
Prevalence
Reproducibility of Results
Tuberculin Test economics
Tuberculin Test methods
Clinical Laboratory Techniques methods
Interferon-gamma Release Tests statistics & numerical data
Latent Tuberculosis diagnosis
Latent Tuberculosis epidemiology
Tuberculin Test statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1532-0987
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 34508026
- Full Text :
- https://doi.org/10.1097/INF.0000000000003338