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If Hoofbeats are not From Horses, It Could be Zebras!! Isolated Hyper-alkaline Phosphatasemia.
- Source :
-
Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2021 Sep-Oct; Vol. 11 (5), pp. 619-622. Date of Electronic Publication: 2020 Dec 17. - Publication Year :
- 2021
-
Abstract
- Alkaline phosphatase (AP) is a membrane bound enzyme and when it is elevated in blood, it is mostly due to either hepatobiliary or bone diseases. We report isolated intestinal hyperphosphatasemia (IAP) in two sisters. Both sisters presented with identical trends of isolated AP elevation. Both underwent extensive workup for liver diseases including cholangiograms, and none was identified. Subsequent isoenzyme electrophoresis showed that 45%-56% of the elevated AP was due to IAP. This elevation of the intestinal AP is consistent with a rare hereditary biochemical abnormality, benign familial intestinal hyperphosphatemia. This condition should be considered in the differential diagnosis of otherwise isolated serum AP levels to avoid unnecessary investigations.<br /> (© 2020 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0973-6883
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of clinical and experimental hepatology
- Publication Type :
- Report
- Accession number :
- 34511824
- Full Text :
- https://doi.org/10.1016/j.jceh.2020.12.001