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T-Lymphoblastic Leukemia/Lymphoma and Thymoma: A Case Report and Review of the Literature of a Rare Association.
- Source :
-
Acta haematologica [Acta Haematol] 2022; Vol. 145 (1), pp. 106-111. Date of Electronic Publication: 2021 Sep 17. - Publication Year :
- 2022
-
Abstract
- The co-occurrence of thymoma and T-lymphoblastic lymphoma/leukemia is an extremely rare but previously reported association that poses a diagnostic and therapeutic challenge. We describe a 67-year-old patient with long-standing untreated B1 thymoma that presented with constitutional symptoms and a painless soft tissue mass on the right chest wall. Pathological analysis of the biopsy from the mass demonstrated T-lymphoblastic leukemia/lymphoma. The patient went through a complicated course, was refractory to several lines of therapy, and eventually underwent allogeneic hematopoietic stem cell transplantation in complete remission from a matched related donor. The association between thymoma and malignant neoplasms has been described in the literature, most notably with colorectal adenocarcinoma and thyroid cancer. Thymoma-associated leukemia is, however, extremely unusual, with limited reports in the literature. Distinguishing between thymoma and leukemia can be challenging and often requires meticulous diagnostic efforts. For patients with a past history of thymoma, awareness of this particular association should be bared in mind to allow earlier diagnosis and therapy.<br /> (© 2021 The Author(s). Published by S. Karger AG, Basel.)
- Subjects :
- Aged
Allografts
Biopsy
Humans
Male
Hematopoietic Stem Cell Transplantation
Neoplasms, Second Primary diagnosis
Neoplasms, Second Primary pathology
Neoplasms, Second Primary therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma diagnosis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma pathology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma therapy
Thymoma diagnosis
Thymoma pathology
Thymoma therapy
Thymus Neoplasms diagnosis
Thymus Neoplasms pathology
Thymus Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9662
- Volume :
- 145
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 34537764
- Full Text :
- https://doi.org/10.1159/000519033